Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Aging is a multidimensional process regulated by the interplay of genetic and environmental factors, with epigenetic alterations serving as a central regulatory hub. Aberrant DNA methylation patterns, dysregulation of histone-modifying enzymes (e.g., SIRT1, EZH2), and non-coding RNA-mediated mechani...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Haikuan Yu, Taojin Feng, Chengcheng Zhang, Zhouguang Jiao, Wenkai Fan, Rongxian Jiang, Dewen Kong, Fubing Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	aging epigenetics age-related diseases pharmacological epigenetics DNA methylation histone modification
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1699296/full