The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset

A fetal pituitary hormone, oxytocin which causes uterine contractions, increases throughout gestation, and its increase reaches 10-fold from week 32 afterward. Oxytocin is, on the other hand, degraded by placental leucine aminopeptidase (P-LAP) which exists in both terminal villi and maternal blood....

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Bibliographic Details

Published in:	European Journal of Obstetrics & Gynecology and Reproductive Biology: X
Main Authors:	Masato Yoshihara, Shigehiko Mizutani, Kunio Matsumoto, Yukio Kato, Yusuke Masuo, Arita Harumasa, Shohei Iyoshi, Sho Tano, Hidesuke Mizutani, Tomomi Kotani, Eita Mizutani, Kiyosumi Shibata, Hiroaki Kajiyama
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Subjects:	Fetal oxytocin Progesterone withdrawal Placental leucine aminopeptidase (P-LAP) Fetal adrenocorticotropin CYP17A in human placenta
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590161323000352