A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin

Abstract Thienamycin, the first representative of carbapenem antibiotics was discovered in the mid-1970s from soil microorganism, Streptomyces cattleya, during the race to discover inhibitors of bacterial peptidoglycan synthesis. Chemically modified into imipenem (N-formimidoyl thienamycin), now one...

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الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Seydina M. Diene, Lucile Pinault, Sophie Alexandra Baron, Saïd Azza, Nicholas Armstrong, Linda Hadjadj, Eric Chabrière, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2021-05-01
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-021-89600-x