Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase
An agonist-occupied β2-adrenergic receptor (β2-AR) recruits G protein receptor kinase-2 (GRK2) which is recruited to the membrane. Thus, the physical proximity of activated β2-AR and PI-3K allows the activation of the latter. In contrast, it has been observed that the β1-AR is unable to activate the...
| Published in: | International Journal of Cell Biology |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Online Access: | http://dx.doi.org/10.1155/2009/959168 |