Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase

An agonist-occupied β2-adrenergic receptor (β2-AR) recruits G protein receptor kinase-2 (GRK2) which is recruited to the membrane. Thus, the physical proximity of activated β2-AR and PI-3K allows the activation of the latter. In contrast, it has been observed that the β1-AR is unable to activate the...

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Bibliographic Details
Published in:	International Journal of Cell Biology
Main Authors:	Julie Simard, Matthieu Boucher, Rachel Massé, Terence E. Hébert, Guy Rousseau
Format:	Article
Language:	English
Published:	Wiley 2009-01-01
Online Access:	http://dx.doi.org/10.1155/2009/959168

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