Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis

IntroductionThis study aims to investigate the progressive impact of chronic iron overload on the olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson’s and Alzheimer’s. The focus is on understanding how iron accumulation leads to oxidative stress, mitoc...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Lin Deng, Qihui Luo, Yucong Liu, Yao Wang, Zongliang Xiong, Hongping Wang, Lu Zhao, Lanlan Jia, Riyi Shi, Chao Huang, Zhengli Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	iron overload mice lipid peroxidation olfactory apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1506944/full