Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells.

Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern genome-editing tools allow researchers to create isoge...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Ksenia N Morozova, Lyubov A Suldina, Tuyana B Malankhanova, Elena V Grigor'eva, Suren M Zakian, Elena Kiseleva, Anastasia A Malakhova
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	http://europepmc.org/articles/PMC6192588?pdf=render