USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice

Abstract Background Tauopathies, including Alzheimer’s disease, are characterized by the pathological aggregation of tau protein, which is strongly linked to dysregulation of the autophagy-lysosomal degradation pathway. However, therapeutic strategies targeting this pathway remain limited. Methods W...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Siyi Zheng, Jiahui Zhu, Cailin Wang, Yanqing Wu, Shangqi Sun, Hongxiu Guo, Yanmin Chang, Rong Ma, Gang Li
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Tau Raptor USP9X Autophagy Alzheimer’s disease
Online Access:	https://doi.org/10.1186/s12964-024-01872-8