Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine (hydroxyputrescine lysine), a polyamine-derived amino acid formed post-translationally in a reaction catalyzed by deoxyhypusine s...
| Published in: | PLoS ONE |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0230627 |