RIPK1 inhibition in malignant cells potentiates immunotherapy and radiotherapy outcome

Apoptosis, necroptosis and pro-inflammatory NF-κB-dependent signaling are repressed by receptor-interacting serine/threonine-protein kinase 1 (RIPK1). A recent paper in Immunity describes a small molecule inducing the proteolytic degradation of RIPK1. In preclinical experiments, this RIPK1 inhibitor...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Jonathan G. Pol, Andrea Checcoli, Manuela Lizarralde-Guerrero, Guido Kroemer
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	Cancer immunotherapy immune checkpoint inhibitor immunogenic cell death necroptosis radiotherapy
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2024.2425465