PGE2 binding to EP2 promotes ureteral stone expulsion by relaxing ureter via the cAMP-PKA pathway

Abstract Background This study investigated the relaxation effect of PGE2 on the ureter and its role in promoting calculi expulsion following calculi development. Methods By using immunofluorescence and Western blot, we were able to locate EP receptors in the ureter. In vitro experiments assessed th...

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Bibliographic Details

Published in:	BMC Urology
Main Authors:	Hao Su, Wenyan Zhou, Weiming Chen, Ke Yang, Meng Yang, Hu He, Cheng Qian, Dongbo Yuan, Kehua Jiang, Jianguo Zhu
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	PGE2 EP2 cAMP Ureteral Calculi Relaxation
Online Access:	https://doi.org/10.1186/s12894-024-01504-w