Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity

We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve the α-amino a...

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发表在:	Molecules
Main Authors:	Teshome Aboye, Christopher J. Meeks, Subhabrata Majumder, Alexander Shekhtman, Kathleen Rodgers, Julio A. Camarero
格式:	文件
语言:	英语
出版:	MDPI AG 2016-01-01
主题:	cyclotide MAS1 receptor angiotensin
在线阅读:	http://www.mdpi.com/1420-3049/21/2/152