The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function

ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALLINIs, namely, BI-D and the drug candidate Pirmiteg...

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Bibliographic Details
Published in:mBio
Main Authors: Matthew R. Singer, Tung Dinh, Lev Levintov, Arun S. Annamalai, Juan S. Rey, Lorenzo Briganti, Nicola J. Cook, Valerie E. Pye, Ian A. Taylor, Kyungjin Kim, Alan N. Engelman, Baek Kim, Juan R. Perilla, Mamuka Kvaratskhelia, Peter Cherepanov
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Subjects:
antiretroviral drugs
HIV-1
integrase
allosteric inhibitor
ALLINI
LEDGIN
Online Access:https://journals.asm.org/doi/10.1128/mbio.03560-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03560-22

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