Computational modeling of DLBCL predicts response to BH3-mimetics
Abstract In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this homeostasis is frequently perturbed in cancer cells due to the overexpression of anti-apoptotic BCL2 family proteins. Variability in the expression and sequ...
| Published in: | npj Systems Biology and Applications |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-06-01
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| Online Access: | https://doi.org/10.1038/s41540-023-00286-5 |