Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis

Enterovirus A71 (EV-A71) causes Hand, Foot, and Mouth Disease and has been clinically associated with neurological complications. However, there is a lack of relevant models to elucidate the neuropathology of EV-A71 and its mechanism, as the current models mainly utilize animal models or immortalize...

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Bibliographic Details

Published in:	Emerging Microbes and Infections
Main Authors:	Wai Hon Chooi, Winanto, Yingying Zeng, Cheryl Yi-Pin Lee, Ze Qin Lim, Pradeep Gautam, Justin Jang Hann Chu, Yuin-Han Loh, Sylvie Alonso, Shi-Yan Ng
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	EV71 Ferritin Ferroptosis Human motor neurons scRNA-Seq Pluripotent stem cells
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2024.2382235