VHL mutation drives human clear cell renal cell carcinoma progression through PI3K/AKT-dependent cholesteryl ester accumulationResearch in context

Summary: Background: Cholesteryl ester (CE) accumulation in intracellular lipid droplets (LDs) is an essential signature of clear cell renal cell carcinoma (ccRCC), but its molecular mechanism and pathological significance remain elusive. Methods: Enabled by the label-free Raman spectromicroscopy,...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Shuo Zhang, Tinghe Fang, Yexuan He, Weichen Feng, Zhuoyang Yu, Yaoyao Zheng, Chi Zhang, Shuai Hu, Zhuojun Liu, Jia Liu, Jian Yu, Han Zhang, Anbang He, Yanqing Gong, Zhisong He, Kaiwei Yang, Zhijun Xi, Wei Yu, Liqun Zhou, Lin Yao, Shuhua Yue
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Stimulated Raman scattering microscopy Raman spectromicroscopy Clear cell renal cell carcinoma Cholesterol metabolism VHL mutation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396424001051