Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations

Glioblastoma, one of the most aggressive and heterogeneous malignant tumors, presents significant challenges for clinical management due to its cellular and metabolic complexity. This review integrates recent advancements in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to eluci...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yixin Fu, Yong Yi, Yongxiang Shao, Jingcheng Jiang, Qingshan Deng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	glioma tumor microenvironment single-cell tumor-associated macrophages metabolic reprogramming
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561388/full