Design, Synthesis, Antitumor Activity and Molecular Docking Study of Novel 5-Deazaalloxazine Analogs

Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted alkylamino), 2-(heterocyclic substituted), 2-amino, 2,4-dioxo and 2-deoxo-5-deazaalloxazine derivatives by app...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Sawsan Mahmoud, Doaa Samaha, Mosaad S. Mohamed, Nageh A. Abou Taleb, Mohamed A. Elsawy, Tomohisa Nagamatsu, Hamed I. Ali
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Subjects:	deazaalloxazine antitumor AutoDock selectivity protein kinase
Online Access:	https://www.mdpi.com/1420-3049/25/11/2518