Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain

Polyketides are a major class of natural products, including bioactive medicines such as erythromycin and rapamycin. They are often rich in stereocenters biosynthesized by the ketoreductase (KR) domain within the polyketide synthase (PKS) assembly line. Previous studies have identified conserved mot...

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Bibliographic Details

Published in:	Beilstein Journal of Organic Chemistry
Main Authors:	Changjun Xiang, Shunyu Yao, Ruoyu Wang, Lihan Zhang
Format:	Article
Language:	English
Published:	Beilstein-Institut 2024-07-01
Subjects:	bioinformatics conserved motifs ketoreductase polyketide synthase stereocontrol
Online Access:	https://doi.org/10.3762/bjoc.20.131