Causal Linkage Between Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Two-Sample Mendelian Randomization Analysis

BackgroundObservational studies suggest an association between inflammatory bowel disease (IBD) [including ulcerative colitis (UC) and Crohn’s disease (CD)] and Primary sclerosing cholangitis (PSC), but the causal association between the two diseases remains unclear.MethodsWe used two-sample Mendeli...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Ying Xie, Xuejie Chen, Minzi Deng, Yuhao Sun, Xiaoyan Wang, Jie Chen, Changzheng Yuan, Therese Hesketh
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	inflammatory bowel disease ulcerative colitis Crohn’s disease mendelian randomization primary sclerosing cholangitis
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.649376/full