Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors

Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycinase, a class C β-lactamase that rapidly hydrolyzes...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Scott T. Lefurgy, Emilia Caselli, Magdalena A. Taracila, Vladimir N. Malashkevich, Beena Biju, Krisztina M. Papp-Wallace, Jeffrey B. Bonanno, Fabio Prati, Steven C. Almo, Robert A. Bonomo
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	β-lactam β-lactamase cephamycinase boronic acid transition-state analog inhibitor
Online Access:	https://www.mdpi.com/2218-273X/10/5/671