Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma.

Caspase-9 is a component of the apoptosome that mediates cell death following release of cytochrome c from mitochondria. Inhibition of Caspase-9 with a dominant negative construct (Casp9DN) blocks apoptosome function, promotes viability and has been implicated in carcinogenesis. Inhibition of the ap...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Sih-han Wang, Sean M Martin, Peter S Harris, C Michael Knudson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3096637?pdf=render