Unraveling autophagic imbalances and therapeutic insights in Mecp2-deficient models

Abstract Loss-of-function mutations in MECP2 are associated to Rett syndrome (RTT), a severe neurodevelopmental disease. Mainly working as a transcriptional regulator, MeCP2 absence leads to gene expression perturbations resulting in deficits of synaptic function and neuronal activity. In addition,...

Full description

Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Alessandro Esposito, Tommaso Seri, Martina Breccia, Marzia Indrigo, Giuseppina De Rocco, Francesca Nuzzolillo, Vanna Denti, Francesca Pappacena, Gaia Tartaglione, Simone Serrao, Giuseppe Paglia, Luca Murru, Stefano de Pretis, Jean-Michel Cioni, Nicoletta Landsberger, Fabrizia Claudia Guarnieri, Michela Palmieri
Format:	Article
Language:	English
Published:	Springer Nature 2024-10-01
Subjects:	Autophagy MeCP2 Metabolism Neurons Rett Syndrome
Online Access:	https://doi.org/10.1038/s44321-024-00151-w