Blocking axon-glial mechanotransduction to prevent concussive brain injury

Highlights A concussive head impact induces axonal varicosities, preceding excitotoxicity-mediated cortical microglial activation and demyelination. Blocking TRPV4 channels before or after head impact suppresses axon-glial and behavioral changes or enhances their recovery, respectively. TRPV4 KO mic...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Chao Sun, Di Ma, Jacob Hansen, Jeffrey R. Tonniges, Hongzhen Hu, Liwen Zhang, Chen Gu
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Online Access:	https://doi.org/10.1186/s40478-025-02117-6