Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a prolonged latent period, even after cessation of expos...

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Bibliographic Details

Published in:	Environmental Health and Preventive Medicine
Main Authors:	Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara
Format:	Article
Language:	English
Published:	Komiyama Printing Co. Ltd 2024-12-01
Subjects:	arsenic cellular senescence sasp cancer liver hepatocellular carcinoma gene expression environment
Online Access:	https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00139/_html/-char/en