The role of FoxO3a in the pathogenesis of osteoarthritis and its therapeutic applications

Osteoarthritis (OA) is a chronic degenerative joint disease predominantly observed in middle-aged and elderly individuals, with its complex pathological mechanisms significantly affecting patients’ quality of life. Due to the absence of effective treatment strategies, there has been a growing emphas...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Zhimin Wu, Xiaofei Wang, Yuxia Yang, Cunyi Xia, Linbing Lou, Wenyong Fei, Jingcheng Wang, Jihang Dai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	FoxO3a osteoarthritis chondrocytes oxidative stress transcription factor
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1650194/full