Three to Tango: MUC1 as a ligand for both E-selectin and ICAM-1 in the breast cancer metastatic cascade

Cancer cell tethering and rolling on the vascular wall is facilitated by various selectin:glycoprotein interactions which lead to eventual extravasation and metastases. The aberrantly underglycosylated mucin MUC1 has been shown to both abundantly express selectin binding moieties (sialyl Lewis x and...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yue eGeng, Kimberly eYeh, Tait eTakatani, Michael R. King
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-07-01
Subjects:	E-Selectin breast cancer Adhesion ICAM-1 Circulation MUC-1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00076/full