Gas6 induces AIM to suppress acute lung injury in mice by inhibiting NLRP3 inflammasome activation and inducing autophagy

IntroductionGrowth arrest-specific 6 (Gas6) protein signaling plays a critical role in maintaining immune homeostasis and regulating inflammation. However, novel mechanisms for modulating macrophage activity through the Gas6 axis are being identified. Gas6 enhances the production of apoptosis inhibi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Seonghee Jeong, Kyungwon Yang, Ye‐Ji Lee, Joo-Won Park, Eun-Mi Park, Jihee Lee Kang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	Gas6 AIM inflammasome autophagy efferocytosis acute lung injury
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523166/full