Mechanism of DUX-induced differentiation of mESC into extraembryonic endoderm

Objective·To explore the effect of double homeobox (DUX) protein on the differentiation potential of mouse embryonic stem cells (mESCs) into extraembryonic endoderm (XEN) and the possible mechanism of its action.Methods·Overexpression of DUX cell lines in mESCs was achieved by using a lentiviral sys...

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Bibliographic Details

Published in:	Shanghai Jiaotong Daxue xuebao. Yixue ban
Main Authors:	HONG Lei, GUO Chuanliang, CAI Qin, LI Wanrui, ZENG Yitao, XUE Yan, ZENG Fanyi
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2024-11-01
Subjects:	mouse embryonic stem cell (mesc) extraembryonic endoderm (xen) double homeobox (dux) retinoic acid signaling pathway
Online Access:	https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1359.shtml