Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Abstract Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So we thought that CPT maybe a potentia...

Full description

Bibliographic Details

Published in:	Chinese Medicine
Main Authors:	Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	Cryptotanshinone Aerobic glycolysis Melanoma PFK AMPK HIF-1α
Online Access:	https://doi.org/10.1186/s13020-024-00913-1