Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons

Abstract Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine release within the striatum. However, the underlying mechanism remains unclear. In this study, a variety of in...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Kedong Zhu, Lanxia Meng, Jiaying Luo, Tingting Wen, Liang Dan, Zhihao Wang, Xuebing Cao, Zhaohui Zhang, Guiqin Chen
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	Taltirelin Dopamine receptor D2 Tyrosine hydroxylase Thyrotropin-releasing hormone receptor
Online Access:	https://doi.org/10.1186/s12967-024-06020-x