Indoxyl Sulfate Mediates the Low Inducibility of the NLRP3 Inflammasome in Hemodialysis Patients

The NLRP3 inflammasome is responsible for the maturation of caspase-1 and interleukin-1β (IL-1β). Despite the study about basal activity of the NLRP3 inflammasome in hemodialysis (HD) patients, little is known about its inducibility in the milieu of uremia. Peripheral blood mononuclear cells (PBMCs)...

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Bibliographic Details
Published in:Toxins
Main Authors: Li-Chun Ho, Ting-Yun Wu, Tsun-Mei Lin, Hung-Hsiang Liou, Shih-Yuan Hung
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Subjects:
NLRP3 inflammasome
indoxyl sulfate
uremia
innate immunity
Online Access:https://www.mdpi.com/2072-6651/13/1/38

Internet

https://www.mdpi.com/2072-6651/13/1/38

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