A psychiatric medication, clozapine, induces autophagy and apoptosis in breast cancer cells through reactive oxygen species.

Cancer patients with psychotic disorders have occasionally exhibited reduced tumor sizes following long-term antipsychotic treatment. Previous studies have shown that antipsychotic drugs, such as clozapine, could inhibit cancer cell proliferation, but the underlying mechanisms remain unclear. This s...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Ya-Chun Fan, Shih-Chao Lin, Po-Jung Lai, Pei-Chun Lai, Germain Maurus, Shiow-Yi Chen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0326224