Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapy

Abstract Background Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine...

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Bibliographic Details

Published in:	Diagnostic Pathology
Main Authors:	Ruihe Lin, Atrayee Basu Mallick, Zi-Xuan Wang, Scot Andrew Brown, Bo Lu, Wei Jiang
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	STRN-NTRK2 fusion Sarcoma Next-generation sequencing Larotrectinib
Online Access:	https://doi.org/10.1186/s13000-023-01400-1