Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

BackgroundColorectal cancer (CRC) shows significant inter-population heterogeneity in its genomic landscape, yet Middle Eastern populations are underrepresented in large-scale sequencing studies. This exploratory study aims to characterize somatic mutations and disrupted signaling pathways in Saudi...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Hanan E. Alatwi, Amnah A. Alharbi, Rashid Mir, Othman R. Alzahrani, Abdulrahman H. Alessa, Yousef M. Hawsawi, Mohammed Ali Arishi, Aziz Dhaher Albalawi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	colorectal cancer Saudi cohort whole-exome sequencing somatic mutation pathway analysis precision oncology
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1679528/full