Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomics

Abstract Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles in tumor progression, antitumor immunity, and TME remodeling. However, a thorough comparative characterization of tumor-TAM crosstalk across IDH-defined categories of gl...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Meysam Motevasseli, Maryam Darvishi, Alireza Khoshnevisan, Mehdi Zeinalizadeh, Hiva Saffar, Shiva Bayat, Ali Najafi, Mohammad Javad Abbaspour, Ali Mamivand, Susan B. Olson, Mina Tabrizi
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Glioblastoma Tumor microenvironment Tumor-associated macrophage Tumor-TAM interaction Immune checkpoint inhibitor
Online Access:	https://doi.org/10.1186/s40478-024-01837-5