Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses. CD27 agonists could therefore be used to bolster cellular vaccines and anti-tumour immune responses. To date, clinical development...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny Kim, H. T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	CD27 TNFRSF costimulation T cells cancer vaccine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252274/full