Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

Abstract Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expressed genes in BPH identified by transcriptome sequencing of 5 hyperpla...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Glutathione peroxidase 3 Benign prostatic hyperplasia Mitochondria-mediated apoptosis Autophagy-related ferroptosis AMPK/ERK1/2 pathway AMPK/mTOR pathway
Online Access:	https://doi.org/10.1186/s12967-023-04432-9