REC protein family expansion by the emergence of a new signaling pathway

ABSTRACTThis report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance. Specificity between residues in REC domain containing response regulators with paired histidine kinases is under negative purifying sel...

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Bibliographic Details

Published in:	mBio
Main Authors:	Megan E. Garber, Vered Frank, Alexey E. Kazakov, Matthew R. Incha, Alberto A. Nava, Hanqiao Zhang, Luis E. Valencia, Jay D. Keasling, Lara Rajeev, Aindrila Mukhopadhyay
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-12-01
Subjects:	large protein families two-component regulatory systems evolution gene regulation genetic recombination domain swapping
Online Access:	https://journals.asm.org/doi/10.1128/mbio.02622-23