Molecular and phenotypic characterization of 5-FU resistant colorectal cancer cells: toward enrichment of cancer stem cells

Abstract Cancer stem cells (CSCs) as a subgroup of cells within a tumor capable of self-renewal, thereby driving tumor initiation and spread. Addressing treatment failures in cancer, linked to CSCs and their resistance mechanisms, requires effective preclinical models for testing targeted therapies....

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Amirhesam Babajnai, Saeed Rahmani, Mohammad Jamal Asadi, Elmira Gheytanchi, Glavizh Adibhesami, Faezeh Vakhshiteh, Zahra Madjd
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Cancer stem cell Colorectal cancer 5-FU, EMT ABC, Drug resistance
Online Access:	https://doi.org/10.1186/s12935-025-03758-2