Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria

Mitochondrial Ca2+ handling is accomplished by balancing Ca2+ uptake, primarily via the Ru360-sensitive mitochondrial calcium uniporter (MCU), Ca2+ buffering in the matrix and Ca2+ efflux mainly via Ca2+ ion exchangers, such as the Na+/Ca2+ exchanger (NCLX) and the Ca2+/H+ exchanger (CHE). The mecha...

Full description

Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Gayathri K. Natarajan, Lyall Glait, Jyotsna Mishra, David F. Stowe, Amadou K. S. Camara, Wai-Meng Kwok
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	CHE Ca2+/H+ exchanger LETM1 calcium retention capacity total matrix Ca2+ cardiac mitochondria
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2020.510600/full