The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo

5-Fluorouracil (5-FU), a chemotherapeutic drug used to treat a variety of cancers, can enter the environment through different routes, causing serious public health and environmental concerns. It has been reported that 5-FU exposure adversely affects male reproductive function, and its effects on th...

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Bibliographic Details

Published in:	Ecotoxicology and Environmental Safety
Main Authors:	Wenzheng Yuan, Guojie Ji, Xiaowei Shi, Zhibin Sun, Chenyan Liu, Yangyang Yu, Wenmi Li, Xiaoyi Wang, Huanhuan Hu
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	5-Fluorouracil Oxidative stress Apoptosis Public health Reproductive toxicity Testis damage
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651324005414