Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid

Lysophosphatidic acid (LPA) is a promising biomarker candidate to screen for ovarian cancer (OC) and potentially stratify and treat patients according to disease stage. LPA is known to target the actin-binding protein gelsolin which is a key regulator of actin filament assembly. Previous studies hav...

全面介绍

书目详细资料

发表在:	Biomolecules
Main Authors:	Katharina Davoudian, Shayon Bhattacharya, Damien Thompson, Michael Thompson
格式:	文件
语言:	英语
出版:	MDPI AG 2023-09-01
主题:	ovarian cancer lysophosphatidic acid gelsolin actin lipid-protein interaction predictive molecular modelling
在线阅读:	https://www.mdpi.com/2218-273X/13/9/1426