Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats

Sleep deprivation (SD) is commonplace in today’s fast-paced society. SD is a severe public health problem globally since it may cause cognitive decline and even neurodegenerative disorders like Alzheimer’s disease. Melatonin (MT) is a natural chemical secreted by the pineal gland with neuroprotectiv...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Chao Yin, Meiya Zhang, Li Cheng, Li Ding, Qing Lv, Zixuan Huang, Jiaqi Zhou, Jianmei Chen, Ping Wang, Shunbo Zhang, Qiuyun You
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	melatonin sleep deprivation cognitive impairmen TLR4/MYD88/NF-κB signaling pathway neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1430599/full