A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo

Abstract The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular gen...

Full description

Bibliographic Details

Published in:	Communications Biology
Main Authors:	Tomas Lagunas, Stephen P. Plassmeyer, Anthony D. Fischer, Ryan Z. Friedman, Michael A. Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K. Sol, Michael J. Kasper, Stuart B. Fass, Alessandra F. Aguilar Lucero, Joon-Yong An, Stephan J. Sanders, Barak A. Cohen, Joseph D. Dougherty
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Online Access:	https://doi.org/10.1038/s42003-023-05483-w