Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53

Background/Aims: PI3KCA and mutant p53 are associated with tumorigenesis and the development of cancers. NVP-BKM120, a selective pan-PI3K inhibitor, exerts the antitumor activity by suppressing the PI3K signaling pathway. Prima-1Met, a low molecular weight compound, can rescue the gain-of-function o...

Full description

Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Zongjuan Li, Xiangdong Xu, Yizhuo Li, Kun Zou, Zhuo Zhang, Xiaoying Xu, Yina Liao, Xinrui Zhao, Wei Jiang, Wendan Yu, Wei Guo, Yiming Chen, Yixin Li, Miao Chen, Wu-guo Deng, Liren Li, Lijuan Zou
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2018-02-01
Subjects:	BKM120 Prima-1Met Akt CPSF4 HTERT P53 Antitumor
Online Access:	https://www.karger.com/Article/FullText/487786