Mechanism and role of H. pylori CagA-induced NLRP3 inflammasome in gastric cancer immune cell infiltration

Abstract The high incidence of gastric cancer in China is strongly associated with widespread Helicobacter pylori infection. While the bacterium’s role in gastric cancer initiation and progression is well-established, the precise molecular mechanisms remain incompletely characterized. Current clinic...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Chuandan Wan, Ping Wang, Yeqiong Xu, Yanping Zhu, Huanhuan Chen, Xuexian Cao, Yulan Gu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	NLRP3 inflammasome Helicobacter pylori Gastric cancer Immune infiltration Prognosis
Online Access:	https://doi.org/10.1038/s41598-025-98301-8