The Natural HASPIN Inhibitor Coumestrol Suppresses Intestinal Polyp Development, Cachexia, and Hypogonadism in a Mouse Model of Familial Adenomatous Polyposis (<i>Apc^Min/+</i>)

(1) Background: HASPIN kinase is involved in regulating spindle function and chromosome segregation, as well as phosphorylating histone H3 at Thr3 in mitotic cells. Several HASPIN inhibitors suppress cancer cell proliferation. It was recently reported that coumestrol from bean sprouts inhibits HASPI...

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Bibliographic Details

Published in:	Biology
Main Authors:	Hiromitsu Tanaka, Shunsuke Matsuyama, Tomoe Ohta, Keisuke Kakazu, Kazutoshi Fujita, Shinichiro Fukuhara, Tetsuji Soda, Yasushi Miyagawa, Akira Tsujimura
Format:	Article
Language:	English
Published:	MDPI AG 2024-09-01
Subjects:	androgen histone H3 anti-aging cancer protein kinase testis
Online Access:	https://www.mdpi.com/2079-7737/13/9/736