α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice
Abstract Pathological forms of α-synuclein contribute to synucleinopathies, including Parkinson’s disease (PD). Most cases of PD arise from gene-environment interactions. Microbiome composition is altered in PD, and gut bacteria are causal to symptoms in animal models. We quantitatively profiled nea...
| Published in: | npj Parkinson's Disease |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41531-024-00816-w |