SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

Son of sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic receptor tyrosine kinase (RTK)‐dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (EGFR) signaling to regu...

Full description

Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
Format:	Article
Language:	English
Published:	Wiley 2024-03-01
Subjects:	acquired resistance EGFR‐TKI osimertinib PI3K RAS SOS2
Online Access:	https://doi.org/10.1002/1878-0261.13564